Led by scientists with extensive experience at top global pharmaceutical enterprises, the Porton Crystallization Technology Platform integrates expertise in solid-state research, crystallization process development, preformulation study, particle engineering, and co-processing. Equipped with industry-leading instrumentation, the platform has solved crystallization challenges for over 800 small-molecule pharmaceutical ingredients and intermediates. We are committed to providing full-process customized solutions for crystal form and crystallization process challenges in the pharmaceutical CMC stage.

Drug Substance
Development

Solid Form
Screen & Selection

Crystallization
Process Development

Preformulation
Evaluations

Particle Engineering
& Co-Processing

Drug Product
Development

Experimental + Computational

Full-spectrum Crystallization Capabilities

Solid-state Studies

Comprehensive Solid-state Screening and Evaluation (salt, co-crystal, polymorph)
Crystal Structure Determination (SCXRD, Micro-ED)
Solid-state Screening for Intermediates (isolation, purification, chiral resolution) and New Modalities (PROTACs, peptides, nucleotides)
Quantitative Analysis of Crystalline Polymorphs and Amorphous
Simulation-assisted Screening
OEB 4 Capability for Solid-state Characterization and Crystallization

Crystallization Process Development and Particle Engineering

Crystallization Process Development and Process Scale-up

Quality Attributes Control: Polymorph, PSD, Morphology, Purity, Residual Solvent, etc.
PAT-integrated and Simulation-assisted Process Development
Scalable Crystallization Processes for Intermediates, APIs, and Novel Modalities (PROTACs, peptides, payload-linkers)

Particle Engineering

Controlled Crystallization and Precipitation Technologies: Growth-dominated or Nucleation-dominated Crystallization, Spherical Crystallization, Continuous Crystallization
Wet Milling and Precise Control over Filtration and Drying
Micronization (jet mill, pin mill, hammer mill), Learn More About Micronization…

Preformulation Evaluation

Drug Developability Assessment (pKa, logP/D, equilibrium solubility, pH solubility profiles)
Chemical and Physical Stability Investigation
Excipient Compatibility Study to Support Formulation Design
PK and Tox Formulation Screening and Development
Enabling Formulation Design for Poorly Soluble Compounds
Dissolution Testing in Aqueous and Biorelevant Media